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UK Infant Sibs Project: Phase One

2006 Pilot

University of London
London, United Kingdom


Studying high-risk groups for developing autism promises to advance our understanding of the early markers of autism and the broader phonotype of the condition. Based on the genetic basis of autism, one of the most clearly identified at-risk groups is the siblings of children with ASD. This approach have been productive and is expected to continue to provide possibility of predicting which infants are likely to develop the overt behavioral symptoms of autism based on early behavioral and brain differences during the first years. This proposal is a 2-year pilot project to establish feasibility and the core of a UK national network for studying infant siblings of children with autism. Establishing a network of labs is important due to the interdisciplinary nature of the studies required, and to increase the sample sizes. In phase 1 we will focus on (1) establishing a suitable battery of tasks for use in the first 24 months of life, and (2) piloting procedures for selecting the most high-risk sample to maximize the efficiency of future studies. This study is a natural expansion of the already successful high risk baby siblings research consortium established under the direction of Autism Speaks and the National Institute of Child Health and Human Development.

Significance: The project brings into the primarily U.S.–based, Autism Speaks-supported Baby Siblings Research Consortium a number of well-established investigators in the U.K. The tasks proposed are similar to those used in other ongoing studies of infant siblings, but represent the integration of neurophysiology and developmental psychology which exists in only a few of the currently existing sites, thus enhancing the overall scientific value and opportunities of the consortium. [BSRC]

Disseminations
TypeDateTitle/Link
Publication12/01/2010Frontal cortex functioning in the infant broader autism phenotype.
Publication12/01/2010Frontal cortex functioning in the infant broader autism phenotype.
Publication10/04/2007Infancy and autism: progress, prospects, and challenges
Publication10/04/2007Infancy and autism: progress, prospects, and challenges
Publication04/11/2011Social and attention factors during infancy and the later emergence of autism characteristics
Publication04/11/2011Social and attention factors during infancy and the later emergence of autism characteristics
Publication03/29/2012Gaze following, gaze reading, and word learning in children at risk for autism
Publication03/29/2012Gaze following, gaze reading, and word learning in children at risk for autism
Publication02/27/2009Visual orienting in the early broader autism phenotype: disengagement and facilitation
Publication02/27/2009Visual orienting in the early broader autism phenotype: disengagement and facilitation
Publication02/01/2010Getting answers from babies about autism
Publication02/01/2010Getting answers from babies about autism
Publication01/01/2013Failure to learn from feedback underlies word learning difficulties in toddlers at risk for autism
Publication01/01/2013Failure to learn from feedback underlies word learning difficulties in toddlers at risk for autism
Publication01/01/2009Neural correlates of eye gaze processing in the infant broader autism phenotype
Publication01/01/2009Neural correlates of eye gaze processing in the infant broader autism phenotype

Status:

Completed

Investigator:

Johnson, Mark

Grant Term:

2 years

Award Type:

Pilot

Grant Amount:

$113,410.00

Institution Website:

http://www.lon.ac.uk

Grant ID:

1292