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Identifying ASD-associated Genetic Risk in the Chromatin Landscape of the Developing Cortex
2019 Predoctoral Fellowships
University of California, San Francisco
San Francisco, California
United States
San Francisco, California
United States
This study will investigate rare and common ASD-associated genetic risk in non-coding areas of the genome that affect chromatin in the developing brain. This work will generate a single-cell catalog of important gene regulators in the developing human cortex and identify ASD-associated variants that could alter their activity, potentially uncovering novel targets for treating the core symptoms of ASD.
- Keywords:
- Genetics
- Genomics
- Gene Knock-Out/ Knock-In Models
- Epigenetics
- Molecular Biology
- Developmental Biology
- Developmental Neuroscience
- Biology
- Screening/ Diagnosis/ Phenotyping
- Etiology/ Risk Factors
- Brain Tissue
| Type | Date | Title/Link |
|---|---|---|
| Publication | 12/15/2021 | Individual human cortical progenitors can produce excitatory and inhibitory neurons |
| Publication | 10/06/2021 | Single-cell epigenomics reveals mechanisms of human cortical development |
Status:
CompletedInvestigator:
Ziffra, RyanMentor:
Nowakowski, TomaszGrant Term:
2 yearsAward Type:
Predoctoral FellowshipsGrant Amount:
$70,000.00Institution Website:
http://www.ucsf.eduGrant ID:
11874