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Identification of novel therapeutic targets for ASD associated PTEN-KO mediated changes in neurons
2019 Predoctoral Fellowships
Dartmouth College
Hanover, New Hampshire
United States
Hanover, New Hampshire
United States
This study will use mice with a PTEN-related genetic variant to identify related proteins that may influence the PTEN phenotype and thus serve as new targets for therapy.
- Keywords:
- Developmental Biology
- Developmental Biology
- Microscopy
- Confocal
- Molecular Biology
- Gene Knock-Out/ Knock-In Models
- Developmental Neuroscience
- Neurobiology
- Biology
- Treatment/ Prevention
- Mice
- Cultured Neurons
- Cell Lines
- Brain Tissue
| Type | Date | Title/Link |
|---|---|---|
| Publication | 12/17/2022 | mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures |
| Publication | 11/01/2022 | Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss |
| Publication | 10/29/2021 | Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease |
| Publication | 03/09/2022 | PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate |
Status:
CompletedInvestigator:
Tariq, KamranMentor:
Bosco, GiovanniGrant Term:
2 yearsAward Type:
Predoctoral FellowshipsGrant Amount:
$70,000.00Institution Website:
http://www.dartmouth.edu/Grant ID:
11857