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IBIS-EARLI Collaboration

2008 Other

University of North Carolina
Chapel Hill, North Carolina
United States


The Infant Brain Imaging Study (IBIS) and Early Autism Risk Longitudinal Investigation (EARLI) are two NIH Autism Center of Excellence Networks that focus on the longitudinal study of high-risk siblings of ASD probands (referred to as ‘high-risk sibs’). The principal goal of the IBIS Network is to conduct a longitudinal MRI/DTI and behavioral study of infants at high risk for an autism spectrum disorder (ASD) to explore the association between major brain and behavior changes thought to occur between 6 and 24 months of age. The principal goal of the EARLI Network is to gather data on a high autism risk cohort from conception to age three in order to explore associations between exposures and biomarkers measured during the prenatal and early-postnatal period with autism risk. The IBIS project is collecting data on 544 high risk sibs and 120 typically developing infants over a five year period starting in July 2007. The EARLI project is collecting data on 1200 families over a seven year enrollment period beginning in January of 2009 with a goal of having data through 36 months of age on 1000 high risk siblings. Both projects are funded by the NICHD.

The goal of the IBIS/EARLI collaboration will be to expand the scope of each project and allow for expanded study of infants at risk for autism. Autism Speaks funding will allow a 5 year collaboration of both sites, to explore gene/environment interactions in brain development and a pooled molecular genetic analysis of over 1700 siblings. In order to do so, Autism Speaks support ensures that DNA from all family members (both parents and proband) will be collected and that a standardized environmental exposure questionnaire be filled out by all participating mothers at the same time points. Finally, funding will be used to collect enhanced phenotypic data from both studies, ensuring that children are followed up to 36 months of age in both studies. [BSRC]

Disseminations
TypeDateTitle/Link
Publication10/21/2015Splenium development and early spoken language in human infants.
Publication10/21/2015Splenium development and early spoken language in human infants.
Publication09/03/2014Repetitive behavior in 12-month-olds later classified with autism spectrum disorder
Publication09/03/2014Repetitive behavior in 12-month-olds later classified with autism spectrum disorder
Publication07/15/2016Development of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity.
Publication07/15/2016Development of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity.
Publication07/15/2014Neurodevelopmental disorders: Accelerating progress in autism through developmental research
Publication07/15/2014Neurodevelopmental disorders: Accelerating progress in autism through developmental research
Publication07/05/2016Emerging Executive Functioning and Motor Development in Infants at High and Low Risk for Autism Spectrum Disorder.
Publication07/05/2016Emerging Executive Functioning and Motor Development in Infants at High and Low Risk for Autism Spectrum Disorder.
Publication03/25/2022Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy
Publication03/25/2022Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy
Publication02/15/2017Early brain development in infants at high risk for autism spectrum disorder
Publication02/15/2017Early brain development in infants at high risk for autism spectrum disorder
Publication02/06/2014Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline
Publication02/06/2014Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline
Publication01/30/2014DTIPrep: quality control of diffusion-weighted images
Publication01/30/2014DTIPrep: quality control of diffusion-weighted images
Publication01/09/2014UNC-Utah NA-MIC framework for DTI fiber tract analysis
Publication01/09/2014UNC-Utah NA-MIC framework for DTI fiber tract analysis
Publication01/03/2019Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder
Publication01/03/2019Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder

Status:

Completed

Investigator:

Piven, Joseph

Grant Term:

5 years

Award Type:

Other

Grant Amount:

$2,513,039.00

Institution Website:

http://www.unc.edu

Grant ID:

6020