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Finding the link between chromatin and autism: Molecular signatures of gene expression regulators

2019 Postdoctoral Fellowships

Massachusetts General Hospital
Boston, Massachusetts
United States


This study will investigate certain autism-related genetic variations (loss of function and missense variants) and their regulatory effect on gene expression that affects neural functioning associated with autism.

Disseminations
TypeDateTitle/Link
Publication12/01/2020New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders
Publication10/24/2022Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models
Publication03/09/2023Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies
Publication03/01/2022Transcriptional patterns of coexpression across autism risk genes converge on established and novel signatures of neurodevelopment
Publication02/15/2022Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models

Status:

Completed

Investigator:

Moyses Oliveira, Mariana

Mentor:

Gusella, James

Grant Term:

2 years

Award Type:

Postdoctoral Fellowships

Grant Amount:

$119,400.00

Institution Website:

http://www.massgeneral.org

Grant ID:

11815