Communication deficits in autism linked to central auditory axonal dysfunction.
2020 Royal Arch Mason Pilot
Chapel Hill, North Carolina
This mouse study will explore the effect of potassium channels in certain neurons on auditory processing. Using a variation of the CNTNAP2 gene, which is associated with human communication deficits, specifically language processing impairments, which are common in people with autism, as well as behavioral measures of auditory temporal processing. Researchers will be looking for evidence that potassium channels are linked to dysfunction of these language-processing networks in mice with this genetic variant and test whether pharmacological interventions can influence these channels and the resulting auditory processing dysfunction. Ultimately, this study will identify if pharmacological treatments can improve hearing deficits in the central auditory system.
Grant Term:1 year
Award Type:Royal Arch Mason Pilot