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The High Risk Siblings Research Consortium was established in 2003 as a collaboration among NIH, Autism Speaks and researchers across the world who share a common mission of developing methods of early detection of ASD. The BSRC scientists have pooled their samples of high risk infant siblings of children with an autism diagnosis, who have been carefully monitored and assessed from infancy through early childhood. Research in this area has generated groundbreaking findings regarding risk factors, developmental trajectories and early behavioral and biological markers prior to diagnosis. The goal of this project is to extend our knowledge of early risk factors and biomarkers for ASD by collecting DNA on probands, siblings and parents. [BSRC]